The way i got mine talking was; open the vems software, open the megatune folder then mtCfg, then there should be a file called "megatune.cfg" open it with notepad and the first line of text will tell you the com port it is using.
I left this as it was then plugged in the usb/serial converter, opened the device manager on the pc, look in ports (COM &LPT), right click on "USB Serial port" open properties then port settings, click advanced, then change the COM port number to whatever the megatune file stated! (i ignored the warning about sharing ports etc.)
It worked for me
so might be worth a try.